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Signal transduction by Fcγ receptors (FcγR) immune-receptor tyrosine-based activation motifs (ITAM) or inhibitory motifs (ITIM). Activating FcγR crosslinking by IgG bound to antigen leads to the phosphorylation of ITAM by Src and SYK kinases. This allows SYK kinase to activate other pathways such as RAS and PI3K. This, in turn, increases the cellular calcium level and phagocytosis of the immune complex. Inhibitory FcγR (FcγRIIB) contains an ITIM and inhibits the activation process.
