Table 1.
Demographic and clinical laboratory data of cases and controls
| Variable | Cases (n = 10) | Controls (n = 5) | p value |
|---|---|---|---|
| Age (years) | 2.7 ± 0.4 | 4.0 ± 0.6 | 0.07 |
| Weight (kg) | 13.1 ± 0.5 | 19.4 ± 2.1 | 0.001 |
| BMI (kg/m2) | 15.4 ± 0.6 | 16.5 ± 1.0 | 0.37 |
| Gender (boys) | 9 | 5 | na |
| Ethnicity | |||
| Caucasian | 5 | 4 | na |
| Black | 5 | 1 | |
| nSAT (%) | 72.6 ± 1.5 | 91.3 ± 2.3 | < 0.0001 |
| DI4 (events per hour) | 26.9 ± 14.2 (n = 9) | 1.5 ± 2.1 (n = 3) | na |
| Clinical lab testing | |||
| CRP mg/L (normal range 0.0–5.0) | 5.7 ± 4.6 | 1.8 ± 1.3 | 0.56 |
| EPO mIU/mL (normal range 2.6–18.5) | 8.1 ± 1.3 | na | na |
| Hemoglobin g/L (normal range 105–135) | 114.5 ± 2.7 | 124.2 ± 1.7 | 0.03 |
| Leukocyte counts and differentials | |||
| White blood cells (× 106) | 10.5 ± 1.2 | 9.5 ± 0.4 | 0.53 |
| Polymorphonuclear cells (%) | 32.2 ± 3.3 | 39.8 ± 4.5 | 0.20 |
| Lymphocytes (%) | 54.6 ± 3.2 | 49.4 ± 4.5 | 0.36 |
| Monocytes (%) | 10.1 ± 0.7 | 8.2 ± 0.5 | 0.09 |
| Cytokine production capacity in PBMC stimulated with LPS (pg/mL) median (min, max) | |||
| IL-1β | 1360 (346; 3510) | 4220 (1660; 5630) | 0.08 |
| IL-6 | 3190 (946; 18,000) | 7000 (3340; 12,100) | 0.13 |
| IL-8 | 39,000 (11,000; 266,000) | 12,100 (6330; 32,600) | 0.03 |
| IL-10 | 47 (2; 358) | 304 (100; 336) | 0.11 |
| IL-12p70 | nd | nd | na |
| TNFα | 277 (124; 745) | 444 (183; 734) | 0.21 |
Italics values indicate p < 0.05
CRP C-reactive protein, DI4 desaturation index 4%, EPO erythropoietin, IL interleukin, LPS lipopolyssacharide, PBMC peripheral blood mononuclear cells, na not applicable, nd not detected, nSAT nadir saturation, TNFα tumor necrosis factor alpha