Table 3.
All-cause and cardiovascular mortality among U.S. Elders, NHANES III (1988–1994)
| Mortality outcome by age group | No. of subjects | No. of deaths | Cumulative mortality (%) | 5-year Mortality aHR (95% CI) | 10-year Mortality aHR (95% CI) | Cumulative mortality aHR (95% CI) |
|---|---|---|---|---|---|---|
| All-cause | ||||||
| Aged 60–74 | ||||||
| No NAFLD | 1122 | 643 | 54.02 | Reference | Reference | Reference |
| NAFLD | 973 | 625 | 66.23* | 1.60 (1.24–1.96)† | 1.22 (1.01–1.49)† | 1.23 (1.07–1.42)† |
| Aged 75 + | 1112 | |||||
| No NAFLD | 715 | 675 | 92.21 | Reference | Reference | Reference |
| NAFLD | 461 | 437 | 94.20 | 1.11 (0.88–1.40) | 1.17 (0.99–1.36) | 1.12 (0.97–1.29) |
| Cardiovascular disease | ||||||
| Aged 60–74 | ||||||
| No NAFLD | 917 | 201 | 15.71 | Reference | Reference | Reference |
| NAFLD | 772 | 188 | 20.46* | 2.12 (1.20–3.75)† | 1.06 (0.73–1.52) | 1.20 (0.95–1.52) |
| Aged 75 + | ||||||
| No NAFLD | 707 | 260 | 34.96 | Reference | Reference | Reference |
| NAFLD | 458 | 175 | 36.36 | 1.05 (0.76–1.44) | 1.13 (0.89–1.42) | 1.07 (0.90–1.26) |
NAFLD was defined as a US FLI score of ≥ 30 in the absence of any other cause of chronic liver disease
Multivariate models were adjusted for male, current smoker, hypertension, hyperlipidemia, advance fibrosis (NFS > .676), and history of CVD and cancer. Age, race, diabetes were not considered because of components of US FLI score
*Significantly different from No NAFLD (p < .05)
†p < .05
abbreviation: CI confidence interval, aHR adjusted Hazard Ratios