Table 2.
Immune system pathways predicted by Reactome 3.5 analysis to be stimulated by proteins present in ESP, immature and mature eggs
| Type of response | ESP | Immature eggs | Mature eggs |
|---|---|---|---|
| Cytokine signalling in immune response | Interferon signalling: Antiviral mechanism | – | – |
| Signalling by Interleukins: IL1, IL3, IL5, GM-CFS, IL4, IL13 | – | – | |
| TNF alpha non-canonical NF-Kappaβ pathway | – | – | |
| Innate immune system | – | Toll-like receptor cascade: Trafficking and processing of endosomal TLR | – |
| Neutrophil degranulation | Neutrophil degranulation | Neutrophil degranulation | |
| Fc gamma receptor (FCGR) dependent phagocytosis | – | – | |
| Fc epsilon receptor (FCERI) signalling; Toll-like receptor cascade | – | – | |
| C-type lectin receptors (CLR’s): CLEC7A (Dectin-1) | – | – | |
| Nucleotide-Binding domain, leucine rich repeat containing receptor (NLR) signalling pathways | – | – | |
| DDX58/IFIHI mediated induction of IFN alpha/beta pathways | – | – | |
| Cytosolic sensors of pathogens associated DNA | – | – | |
| Adaptive immune system | MHC class II antigen presentation | MHC class II antigen presentation | MHC class II antigen presentation |
| RAP-1 signalling | RAP-1 signalling | – | |
| MHC class I mediated antigen processing and presentation | – | – | |
| Signalling by the B cell receptor | – | – | |
| TRL signalling | – | – |
Note: Analysis performed using the software Reactome 3.5