Table 4.

Multivariate analysis of PFS and OS in paired patients (N = 83)

	Cox’s regression for PFS				Cox’s regression for OS
	HR	95% Cl	P value	PA	HR	95% Cl	P value	PA
ISUP
≥ 3 vs < 3	2.18	0.89–5.31	0.09	0.546	12.1	0.99–147.1	0.05	0.576
Nephrectomy
Yes vs No					0.03	0.004–0.25	0.001	0.525
IMDC				0.615				0.618
Low	Ref.	Ref.	0.04		Ref.	Ref.	0.17
Intermediate	1.12	0.5–2.51	0.78		1.21	0.35–4.18	0.8
High	2.54	1.08–5.97	0.03		2.71	0.76–9.58	0.12
Laboratory parameters
WBC					1.02	1.01–1.04	0.002	0.624
Na					0.93	0.82–1.06	0.26	0.556
PD-L1 positive (P)a					0.98	0.35–2.77	0.97	0.583
Cox model without PD-L1								0.754
Cox model with PD-L1								0.757

^aP, Primary tumor

Abbreviations: ISUP International Society of Urological Pathology, IMDC International Metastatic Renal-Cell Carcinoma Database Consortium