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. 2019 Apr 16;19:100. doi: 10.1186/s12935-019-0822-1

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Signature-based risk score is a promising marker in the training cohort. a Risk score distribution. b Survival overview. c Heatmap showing the expression profiles of the signature in low- and high-risk groups. d Patients in the high-risk group exhibited worse overall survival compared to those in the low-risk group. e GSEA revealed most significant hallmarks correlated with the high-risk group