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. 2019 Apr 16;18:101. doi: 10.1186/s12944-019-1039-y

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Scheme of long-chain polyunsaturated fatty acid (LCPUFA) metabolism. LCPUFA in the body has two origins. One is the direct incorporation from dietary animal foods, and the other is the biosynthesis from n-6 or n-3 precursor PUFA, linoleic acid (LA) or α–linolenic acid (ALA), respectively. All the fatty acids including LCPUFA are mainly metabolized to CO₂ by β–oxidation and excreted in the breath