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. 2019 Mar 26;12(1):45. doi: 10.3390/ph12010045

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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APELA is co-expressed with the stem cell marker Nestin at the mRNA level in GBM tumor tissue. Slides were prepared from normal brain (NB) and GBM tumor tissue, subjected to RNA-ISH using the RNAscope technology and images analyzed by confocal microscopy. RNA-ISH was performed with individual gene probes for APELA (green), and Nestin (magenta). Nuclei were DAPI counterstained (blue). Colocalization of APELA and Nestin expression in a cluster of individual cells is evident in the merged image (20× tile-scan magnification) and the 4× magnification of the merged image.