Table 2.

Selection of serine/threonine-specific kinases (STKs) shown to be inhibited by natural compounds.

Protein Kinase	Natural Compound
PI3K	Apigenin, Fisetin, Naringenin, Silibinin, Parthenolide, Oridonin, Honokiol, Genistein, EGCG, Taxifolin, Ellagic acid, Emodin, Curcumin
AKT	Apigenin, Fisetin, Quercetin, Naringenin, Silibinin, Parthenolide, Oridonin, Curcumin EGCG, Luteolin, Resveratrol, Genistein, Taxifolin, Wedelolactone, Ellagic acid, Emodin, Harmine, Curcumin
mTOR	Apigenin, Quercetin, Genistein, EGCG, Curcumin, Oridonin, Silibinin, Wedelolactone, Curcumin
GSK3β	Apigenin, Curcumin, Berberine, Resveratrol, Curcumin, Luteolin, Quercetin, Curcumin
CK2	Apigenin, Coumestrol, Resorufin, Gallaflavin, Fisetin, Nortangeretin, Ellagic acid
RAF	Curcumin, EGCG, Resveratrol, Parthenolide
MEK/ERK1/2	Apigenin, Quercetin, Silibinin, Oridonin, Genistein, Parthenolide, Genistein, Honokiol, Cyanidin, Berberine, Quercetin, Ellagic acid, Emodin
PKC	Apigenin, Wedelolactone, Curcumin
CamKK	Apigenin, Curcumin, Resveratrol, Berberine, EGCG (stimulation)
IKK	Apigenin, Wedelolactone
JNK	Apigenin, Quercetin, Silibinin, Cyanidin, Parthenolide, Hesperetin