Table 5.
TRP expression patterns in lung cells.
| Lung Cell | TRPA1 | TRPC6 | TRPV1 | TRPV4 |
|---|---|---|---|---|
| Bronchial epi. | −/+[44] 1, [43] 3 | +[123] 2 | +[124] 3 | +[92] 2 |
| Airway SMC | −/+[44] 1 | +[123] 2 | +[70] 3 | +[104] 2 |
| AT1 cells | −/+[44] 1 | ? | ? | ? |
| AT2 cells | −/+[44] 4 | ? | ? | ? |
| Alveolar MP | ? | +[22] 4 | ? | +[125] 5 |
| Endothelium | −/+[44] 1 | +[19] 4 | +[126] 2 | +[126] 2 |
| PASMC | −/+[44] 1 | +[18] 2 | +[127] 4 | +[127] 2 |
| Neutrophils | ? | +[23] 3 | ? | +[23] 2 |
| Fibroblasts | −/+[44] 1 | −/+[21] 2 | ? | +[128] 4 |
| Myofibroblasts | ? | +[21] 4 | ? | +[128] 4 |
−/+, very low expression, +, expression, ++, high expression, ?, not tested. References in brackets []. Detection by: 1 labeling of specific mRNA (nanostring® technology); 2 amplification of specific mRNA by quantitative reverse transcription (qRT)-PCR; 3 imunohistochemistry, 4 labeling protein by specific antibodies in a Western Blot, 5 functional assays.