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TICs from the originator (A) and the proposed biosimilar (B) after tryptic digestion. The main differences between the TICs are pointed out with the black arrows. The extracted ion chromatograms (XICs) for the (276)TPEVTCVVVDVSHEDPEVK(294) peptide in Enbrel-G and Altebrel-8 for the non-modified (C) and amidated (D) peptide at glutamic acid 292 can be observed. The amidated peptide is eluted at a different time compared to its non-modified counterpart.
