Table 2.
Prediction of hepatitis B virus reactivation in HBeAg-negative chronic HBV infection by serum HBV RNA levels
| Variables | HBV RNA >2.11(log copies/mL) |
HBV DNA >3.39(log copies/mL) | HBsAg>2.74(log IU/mL) | HBV RNA >2.11(log copies/mL) & HBsAg>2.74(log IU/mL) |
HBV DNA >3.39(log copies/mL) & HBsAg>2.74(log IU/mL) |
|---|---|---|---|---|---|
| Sensitivity(%) | 84.21 | 75.4 | 70.17 | 59.64 | 56.14 |
| Specificity(%) | 73.68 | 80.26 | 42.11 | 81.58 | 86.84 |
| PPV(%) | 70.59 | 74.13 | 47.62 | 70.83 | 76.19 |
| NPV(%) | 86.15 | 81.33 | 65.31 | 72.94 | 72.52 |
| Diagnostic accuracy(%) | 78.19 | 78.19 | 54.13 | 72.18 | 73.68 |
| P value* |
χ2 = 1.362 P = 0.243 |
χ2 = 3.189 P = 0.074 |
χ2 = 8.515 P = 0.004 |
χ2 = 10.729 P = 0.001 |
|
| P value# |
χ2 = 0.928 P = 0.335 |
χ2 = 15.545 P = 0.000 |
χ2 = 1.364 P = 0.243 |
χ2 = 4.153 P = 0.042 |
HBV hepatitis B virus, HBsAg Hepatitis B surface antigen, PPV positive predictive value, NPV negative predictive value;*P value of the sensitivity comparison of RNA and other viral markers; #P value of the specificity comparison of RNA and other markers; HBV RNA, HBV DNA and HBsAg cutoff value were obtained from ROC curve analysis