Table 3.
Relationship between MMP-9 polymorphism and IS risk
| SNP | Model | Genotype | control | case | OR (95% CI) | P-value | AIC | BIC |
|---|---|---|---|---|---|---|---|---|
| rs3787268 | Codominant | G/G | 104 (41.9%) | 77 (30.8%) | 1.00 | 0.035* | 689.7 | 702.3 |
| G/A | 104 (41.9%) | 125 (50%) | 1.62 (1.10–2.41) | |||||
| A/A | 40 (16.1%) | 48 (19.2%) | 1.62 (0.97–2.71) | |||||
| Dominant | G/G | 104 (41.9%) | 77 (30.8%) | 1.00 | 0.009* | 687.7 | 696.1 | |
| G/A-A/A | 144 (58.1%) | 173 (69.2%) | 1.62 (1.12–2.35) | |||||
| Recessive | G/G-G/A | 208 (83.9%) | 202 (80.8%) | 1.00 | 0.370 | 693.6 | 702 | |
| A/A | 40 (16.1%) | 48 (19.2%) | 1.24 (0.78–1.96) | |||||
| Overdominant | G/G-A/A | 144 (58.1%) | 125 (50%) | 1.00 | 0.071 | 691.1 | 699.5 | |
| G/A | 104 (41.9%) | 125 (50%) | 1.38 (0.97–1.97) | |||||
| Log-additive | – | – | – | 1.33 (1.03–1.70) | 0.026* | 689.4 | 697.8 | |
| rs3918249 | Co-dominant | C/C | 145 (58.2%) | 155 (62.5%) | 1.00 | 0.240 | 692.1 | 704.8 |
| T/C | 83 (33.3%) | 81 (32.7%) | 0.91 (0.62–1.34) | |||||
| T/T | 21 (8.4%) | 12 (4.8%) | 0.53 (0.25–1.13) | |||||
| Dominant | C/C | 145 (58.2%) | 155 (62.5%) | 1.00 | 0.330 | 692 | 700.5 | |
| T/C-T/T | 104 (41.8%) | 93 (37.5%) | 0.84 (0.58–1.20) | |||||
| Recessive | C/C-T/C | 228 (91.6%) | 236 (95.2%) | 1.00 | 0.110 | 690.4 | 698.8 | |
| T/T | 21 (8.4%) | 12 (4.8%) | 0.55 (0.27–1.15) | |||||
| Over-dominant | C/C-T/T | 166 (66.7%) | 167 (67.3%) | 1.00 | 0.870 | 693 | 701.4 | |
| T/C | 83 (33.3%) | 81 (32.7%) | 0.97 (0.67–1.41) | |||||
| Log-additive | – | – | – | 0.81 (0.61–1.08) | 0.160 | 691 | 699.4 | |
| rs2274755 | – | G/G | 184 (73.9%) | 191 (76.7%) | 1.00 | 0.470 | 693.8 | 702.3 |
| G/T | 65 (26.1%) | 58 (23.3%) | 0.86 (0.57–1.29) | |||||
| rs3918254 | Co-dominant | C/C | 152 (61%) | 152 (61%) | 1.00 | 0.830 | 696 | 708.6 |
| T/C | 81 (32.5%) | 84 (33.7%) | 1.04 (0.71–1.52) | |||||
| T/T | 16 (6.4%) | 13 (5.2%) | 0.81 (0.38–1.75) | |||||
| Dominant | C/C | 152 (61%) | 152 (61%) | 1.00 | NA | 694.4 | 702.8 | |
| T/C-T/T | 97 (39%) | 97 (39%) | 1.00 (0.70–1.43) | |||||
| Recessive | C/C-T/C | 233 (93.6%) | 236 (94.8%) | 1.00 | 0.570 | 694 | 702.5 | |
| T/T | 16 (6.4%) | 13 (5.2%) | 0.80 (0.38–1.70) | |||||
| Over-dominant | C/C-T/T | 168 (67.5%) | 165 (66.3%) | 1.00 | 0.780 | 694.3 | 702.7 | |
| T/C | 81 (32.5%) | 84 (33.7%) | 1.06 (0.73–1.53) | |||||
| Log-additive | – | – | – | 0.97 (0.72–1.29) | 0.820 | 694.3 | 702.7 |
ORs, odds ratios; CI: confidence interval; AIC: Akaike’s Information criterion; BIC: Bayesian Information criterion
*p value ≤0.05 indicates statistical significance