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. 2019 Apr 16;19:101. doi: 10.1186/s12935-019-0813-2

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — HHLA2 expression in human ccRCC tissues. a The positive staining of HHLA2 could be predominantly found in the cytoplasm and on the membrane of the cancer cells in ccRCC tissues. b Weak staining of HHLA2 was found in adjacent normal tissues. c The staining intensity of HHLA2 in human ccRCC tissues was significantly higher than that in adjacent normal tissues (P < 0.0001). d The overall survival rate of ccRCC patients with low HHLA2 expression was significantly higher than that of the patients with high HHLA2 expression (HR = 3.141, 95% CI 1.831–9.238, P = 0.007)