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. 2019 Mar 12;48(13):4299–4313. doi: 10.1039/c8dt04454f

Table 1. Log P and log D7.4 values and RCY, at different ligand concentrations, of 68Ga complexes (average ± standard deviation (N = 4 for log P and log D7.4, N = 3 for RCY).

  [Ga(THPMe)] [Ga(THPH)] [Ga(THPO)]
Log P –3.33 ± 0.02 –2.40 ± 0.02 –1.64 ± 0.01
Log D7.4 –3.27 ± 0.02 –2.28 ± 0.05 –1.65 ± 0.03
Radiochemical yield
100 μM 96.9 ± 1.0 98.9 ± 0.7 95.6 ± 0.2
10 μM 97.8 ± 0.5 99.1 ± 0.2 83.0 ± 0.4
1 μM 96.7 ± 0.2 98.1 ± 0.4 27.5 ± 0.7
0.1 μM a 83.0 ± 0.5 93.9 ± 0.4 N/A

aRadiolabelling performed with 68Ga eluate from a second E&Z generator, eluted with clinical grade HCl.