Table 1. Log P and log D7.4 values and RCY, at different ligand concentrations, of 68Ga complexes (average ± standard deviation (N = 4 for log P and log D7.4, N = 3 for RCY).
[Ga(THPMe)] | [Ga(THPH)] | [Ga(THPO)] | |
Log P | –3.33 ± 0.02 | –2.40 ± 0.02 | –1.64 ± 0.01 |
Log D7.4 | –3.27 ± 0.02 | –2.28 ± 0.05 | –1.65 ± 0.03 |
Radiochemical yield | |||
100 μM | 96.9 ± 1.0 | 98.9 ± 0.7 | 95.6 ± 0.2 |
10 μM | 97.8 ± 0.5 | 99.1 ± 0.2 | 83.0 ± 0.4 |
1 μM | 96.7 ± 0.2 | 98.1 ± 0.4 | 27.5 ± 0.7 |
0.1 μM a | 83.0 ± 0.5 | 93.9 ± 0.4 | N/A |
aRadiolabelling performed with 68Ga eluate from a second E&Z generator, eluted with clinical grade HCl.