Table 2.

Dementia risk due to pSS and other comorbidities

	Univariate analysis		Multivariate analysis
	HR	95% CI	Adjusted HR*	95% CI
Disease
pSS	1.338***	(1.215–1.472)	1.246***	(1.123–1.384)
Gender
Female (ref.)	1.000		1.000
Male	2.130***	(1.860–2.440)	0.865	(0.762–0.982)
Age group
≤60 (ref.)	1.000		1.000
61–70	20.51***	(16.98–24.78)	17.06***	(14.04–20.73)
71–80	57.00***	(47.42–68.54)	42.30***	(34.78–51.44)
>80	102.2***	(82.89–126.1)	77.73***	(62.59–96.54)
Comorbidities
Diabetes	3.762***	(3.319–4.263)	1.608***	(1.431–1.808)
Hyperlipidemia	2.011***	(1.781–2.270)	0.958	(0.853–1.075)
Hypertension	5.198***	(4.677–5.778)	1.353***	(1.216–1.505)
Heart failure	3.650***	(2.858–4.662)	0.914	(0.719–1.161)
Cardiovascular disease	2.615***	(2.351–2.908)	1.380***	(1.247–1.526)
Stroke	5.159***	(4.539–5.863)	1.755***	(1.549–1.990)
Major psychosis or a substance‐related disorder	3.414***	(2.860–4.076)	3.296***	(2.811–3.865)
Traumatic brain injury	3.067***	(2.150–4.376)	1.556	(1.145–2.114)

Adjusted HR*: adjusted by age groups, gender, and the comorbidities.

*P value for HR <0.05, **P value for HR <0.01, ***P value for HR <0.001.