Table 1.

Participating H3Africa Consortium Projects that constitute CHAIR

Project (PI reference)	Descriptive title	Study design	Countries involved in recruitment	Current sample size (target sample size)/sources
ACCME (Adebomowo)8	African Collaborative Center for Microbiome and Genomics Research	Prospective cohort study	Nigeria	Population-based sample of 11 700 female participants (targeted)
AWI-Gen (Ramsay and Sankoh)9	Genomic and Environmental Risk Factors for Cardiometabolic Disease in Africans	Cross-sectional: population-based cohort of adults	Burkina Faso Ghana Kenya South Africa	Community-based (randomized by household and unrelated individuals) 11 057 (targeted: ∼12 000) participants
DM Group (Motala)10	Burden, spectrum and aetiology of type 2 diabetes in sub-Saharan Africa	Cros-sectional: clinical and population-based cohort	Cameroon Guinea Malawi Nigeria South Africa Tanzania Uganda	Health facility-based recruitment of cases and community(population)-based recruitment of controls 3657 (targeted: ∼6000 DM cases and ∼6000 DM-free controls)
Kidney Group (Adu and Ojo)11	H3Africa Kidney Disease Research Network	Prospective and population-based cohort	Ghana Ethiopia Kenya Nigeria	Cases: outpatient clinics and patient admissions Controls: outpatient clinics 7964 (targeted: ∼4000 kidney disease cases and ∼4000 kidney disease-free controls)
RHDGen (Mayosi)12	Genetics of rheumatic heart disease (RHDGen) Network	Case-control cohort and family trios	Kenya Mozambique Namibia Nigeria South Africa Sudan Uganda Zambia	Hospital-based recruitment of cases and community-based controls with no valvular heart disease 3555 (targeted: ∼2700 RHD cases, ∼2700 RHD-free controls and ∼200 family trios)
SIREN (Owolabi and Ovbiagele)13,14	Stroke Investigative Research and Educational Network	Prospective and population-based cohort	Ghana Nigeria	Hospital-based cases, community and hospital-based controls 3811 (∼3000 stroke cases and ∼3000 stroke-free controls)

PI, Principal investigator (www.h3a.org).