TABLE 3.
Relationship between decreasing sex hormone levels and clinical measures in pulmonary arterial hypertension (PAH) cases
| Estimate (95% CI) | p-value | |
|---|---|---|
| 6MWD m | ||
| Ln(oestradiol) | 32.4 (3.5 to 61.4) | 0.03 |
| Ln(DHEA-S) | −30.2 (−54.0 to −6.5) | 0.01 |
| Ln(total testosterone) | −0.8 (−26.6 to 24.9) | 0.95 |
| Ln(SHBG) | 24.5 (−30.9 to 79.9) | 0.38 |
| Right atrial pressure mmHg | ||
| Ln(oestradiol) | −1.6 (−2.8 to −0.3) | 0.02 |
| Ln(DHEA-S) | 1.6 (0.8 to 2.4) | <0.001 |
| Ln(total testosterone) | 0.5 (−0.7 to 1.6) | 0.43 |
| Ln(SHBG) | −0.4 (−2.5 to 1.8) | 0.73 |
| mPAP mmHg | ||
| Ln(oestradiol) | 0.6 (−2.3 to 3.6) | 0.68 |
| Ln(DHEA-S) | 3.6 (1.8 to 5.4) | <0.001 |
| Ln(total testosterone) | 2.8 (0.0 to −5.5) | 0.05 |
| Ln(SHBG) | 3.0 (−2.5 to 8.4) | 0.28 |
| Cardiac output L·min−1 | ||
| Ln(oestradiol) | 0.0 (−0.3 to 0.3) | 0.85 |
| Ln(DHEA-S) | −0.2 (−0.4 to 0.0) | 0.07 |
| Ln(total testosterone) | 0.1 (−0.1 to 0.4) | 0.30 |
| Ln(SHBG) | −0.3 (−0.8 to 0.3) | 0.37 |
| PVR Wood units | ||
| Ln(oestradiol) | 0.4 (−0.3 to 1.0) | 0.27 |
| Ln(DHEA-S) | 0.9 (0.3 to 1.5) | 0.002 |
| Ln(total testosterone) | 0.4 (−0.4 to 1.1) | 0.36 |
| Ln(SHBG) | 0.8 (−0.7 to 2.3) | 0.31 |
| RVSP mmHg | ||
| Ln(oestradiol) | −0.9 (−6.6 to 4.7) | 0.74 |
| Ln(DHEA-S) | 5.6 (1.3 to 9.9) | 0.01 |
| Ln(total testosterone) | 3.0 (−2.9 to 9.0) | 0.31 |
| Ln(SHBG) | −2.9 (−14.4 to 8.5) | 0.61 |
| BNP pg·mL−1 | ||
| Ln(oestradiol) | −101.4 (−241.0 to 38.4) | 0.15 |
| Ln(DHEA-S) | 70.1 (1.5 to 141.8) | 0.06 |
| Ln(total testosterone) | 71.8 (−9.4 to 153.0) | 0.08 |
| Ln(SHBG) | −97.6 (−314.9 to 119.6) | 0.37 |
Adjusted for age and body mass index. 6MWD: 6-min walking distance; DHEA-S: dehydroepiandrosterone-sulfate; SHBG: sex hormone-binding globulin; mPAP: mean pulmonary artery pressure; PVR: pulmonary vascular resistance; RVSP: right ventricular systolic pressure; BNP: brain natriuretic peptide.