Table 5.
Median Within-Person Coefficients of Variation According to Clinical Characteristics
| Characteristic | Scr | CysC | BTP | B2M | UACR, Random | UACR, First am | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No diabetes | 4.0 | 2.0–6.1) | 4.5 | (3.0–6.0) | 5.5 | (3.2–78) | 5.7 | (3.6–78) | 31.7 | (18.3–45.1) | 32.5 | (22.0–43.0) |
| Diabetes | 7.6 | 4.9–10.3) | 3.7 | (1.6–5.8) | 10.0 | (7.3–12.7) | 3.4 | (0.6–6.2) | 24.3 | (10.5–38.2) | 33.4 | 11.5–55.4) |
| No ACEi/ARB | 4.0 | 1.1–7.0) | 4.5 | (2.2–6.8) | 8.3 | (5.3–11.4) | 5.3 | (1.5–9.1) | 35.6 | (13.9–57.2) | 30.0 | 8.6–51.3) |
| ACEi/ARB | 5.5 | 3.0–8.0) | 4.1 | (2.7–5.5) | 6.8 | (4.3–9.3) | 5.6 | (3.5–76) | 29.7 | (1 7.3–42.2) | 32.5 | 19.2–45.8) |
| No diuretic use | 5.4 | 2.6–8.2) | 3.3 | (2.0–4.7) | 8.7 | (5.3–12.1) | 5.4 | (3.5–72) | 36.2 | (23.8–48.5) | 32.6 | 21.9–43.4) |
| Diuretic use | 5.2 | 2.1–8.3) | 5.6 | (4.1–7.2) | 6.2 | (3.7–8.7) | 6.6 | (2.8–10.3) | 25.9 | (10.4–41.5) | 32.0 | 4.5–59.4) |
| Male sex | 4.4 | 2.3–6.5) | 2.9 | (1.7–4.0) | 8.0 | (5.2–10.7) | 3.4 | (1.1–5.7) | 28.9 | (20.1–37.7) | 32.0 | 15.2–48.7) |
| Female sex | 6.3 | 1.7–11.0) | 5.0 | (3.4–6.5) | 5.3 | (2.4–8.1) | 6.2 | (4.4–8.1) | 41.4 | (19.0–63.7) | 32.6 | 18.9–46.3) |
| Nonblack | 4.0 | 2.3–5.8) | 4.0 | (2.6–5.4) | 8.3 | (6.0–10.5) | 5.1 | (2.6–7.6) | 31.7 | (19.7–43.7) | 32.6 | 15.4–49.9) |
| Black | 7.6 | 3.1–12.1) | 4.9 | (2.8–6.9) | 4.9 | (2.1–77) | 5.7 | (3.0–8.4) | 28.3 | (11.1–45.5) | 32.2 | 20.0–44.4) |
| Age ≤ median | 3.8 | 1.2–6.4) | 5.1 | (3.6–6.6) | 5.3 | (3.0–77) | 6.8 | (4.5–9.0) | 27.2 | (13.2–41.2) | 28.1 | 1 7.3–38.8) |
| Age > median | 6.8 | 4.1–9.4) | 2.9 | (1.4–4.4) | 8.8 | (5.9–11.7) | 3.2 | (1.1–5.4) | 37.2 | (25.3–49.0) | 48.7 | 31.6–65.8) |
| SBP ≤ median | 4.9 | 1.5–8.3) | 3.8 | (2.3–5.4) | 7.7 | (3.9–11.4) | 5.8 | (3.2–8.4) | 31.3 | (19.0–43.6) | 33.0 | 11.8–54.2) |
| SBP > median | 5.5 | 3.2–78) | 4.9 | (3.1–6.6) | 7.2 | (4.7–9.7) | 5.4 | (3.0–78) | 29.7 | (11.8–47.7) | 32.3 | 22.3–42.3) |
| eGFR ≤ median | 5.7 | 2.3–9.0) | 4.3 | (2.9–5.7) | 7.0 | (4.0–10.0) | 5.6 | (3.1–8.1) | 26.4 | (12.9–39.9) | 27.2 | 13.6–40.9) |
| eGFR > median | 4.3 | 1.7–6.9) | 4.6 | (2.6–6.7) | 7.5 | (3.8–11.1) | 5.5 | (2.4–8.7) | 37.2 | (24.5–49.8) | 46.7 | 28.8–64.7) |
| Random UACR ≤ median | 6.1 | 3.2–9.0) | 3.8 | (2.1–5.5) | 7.7 | (5.1–10.4) | 4.6 | (1.5–76) | 31.3 | (19.7–42.9) | 43.8 | 13.7–73.9) |
| Random UACR > median | 4.3 | 1.3–73) | 4.9 | (3.4–6.3) | 5.1 | (1.6–8.7) | 5.8 | (3.8–78) | 28.5 | (11.4–45.5) | 30.6 | 24.7–36.6) |
| First AM UACR ≤ median | 4.9 | 2.6–71) | 3.8 | (2.5–5.1) | 7.7 | (5.2–10.2) | 3.5 | (0.7–6.3) | 31.3 | (20.1–42.5) | 36.7 | 9.8–63.6) |
| First AM UACR > median | 5.6 | 2.3–8.9) | 4.9 | (3.3–6.4) | 6.8 | (3.2–10.3) | 5.6 | (3.7–74) | 29.7 | (9.1–50.3) | 32.3 | 23.9–40.6) |
Note: Results are expressed as percentages (95% confidence interval). Median values were age 60 years, SBP of 131 mm Hg, eGFR of 40 mL/min/1.73 m2, random UACR of 142 mg/g, and first am UACR of 125 mg/g.
Abbreviations: ACEi, angiotensin-converting enzyme inhibitor; ARB, angiotensin receptor blocker; B2M, β2-microglobulin; BTP, beta trace protein; CysC, cystatin C; eGFR, estimated glomerular filtration rate; Scr, serum creatinine; SBP, systolic blood pressure; UACR, urinary albumin-creatinine ratio.