Table 2.

In Vitro Potency and Efficacy Data of Amide and Triazole-Containing Potentiators in the VX-770 Chemical Series in CFBE41o⁻ and FRT Cells.^[a]

		EC50 (nM)[b]				Maximal Response[c]
compd	WT CFBE	F508del CFBE	G551D CFBE	G551D FRT	WT CFBE	F508del CFBE	G551D CFBE	G551D FRT
VX-770	36.5 ± 21.3	1889 ± 1388	77.7 ± 27.2	428.5 ± 167.3	100.0%	100.0%	100.0%	100.0%
36	--	--	26.7± 79.4	--	Inactived	Inactived	63.5%	Inactived
37	21.8 ± 41.2	37.1 ± 48.2	18.5 ± 23.4	81.45 ± 102.8	47.5%	36.3%	72.0%	36.7%
56	Inactive across all cell and CFTR typesd
58	Inactive across all cell and CFTR typesd
60	Inactive across all cell and CFTR typesd

^aCFBE41o⁻ abbreviated as CFBE.

^bMean and standard deviation values from at least three determinations are reported.

^cMaximal response is reported as % activity of the VX-770 response.

^dNo statistically significant response above DMSO vehicle.