Table 3. Human orthologs of ion channel candidates identified in screen.
| Drosophila melanogaster Gene | Human Ortholog* |
|---|---|
| Calcium Channels | |
| stj | CACNA2D3 |
| SERCA | ATP2A1 |
| brv2 | PKD1L2 |
| Stim | STIM1 |
| nan | TRPV6 |
| inaF-A;B;C | none |
| wtrw | none |
| Sodium Channels | |
| NaCP60E | SCN8A |
| narrow abdomen | NALCN |
| unc80 | UNC80 |
| unc79 | UNC79 |
| rpk | ASIC2 |
| ppk | ASIC2 |
| ppk25 | ASIC4 |
| ppk30 | ASIC3 |
| ppk17 | none |
| Teh1 | none |
| Potassium Channels | |
| Task6 | KCNK9 |
| SLO2 | KCNT1 |
| Shaker | KCNA1 |
| KCNQ | KCNQ4 |
| Irk1 | KCNJ2 |
| Irk2 | KCNJ2 |
| Irk3 | KCNJ2 |
| Chloride Channels | |
| Best1 | BEST2 |
| Best2 | BEST4 |
| Best3 | BEST4 |
| Rdl | GLRA4 |
| GluClα | GLRA1 |
| Ligand-gated Cation Channels | |
| GluRIIB | GRIK1 |
| mAChR-A | CHRM1 |
| nAChRα7 | CHRNA7 |
| nAChRα6 | CHRNA7 |
| nAChRα5 | CHRNA7 |
| Or47a | none |
| Ir7b | none |
| Ir67a | none |
| Ir76a | none |
| Ir84a | none |
| Ir92a | none |
| Ir94g | none |
| Ir94h | none |
| Other | |
| CG18549 | MFSD11 |
| Inx3 | none |
*
Human orthologs were identified using the DRSC Integrative Ortholog Prediction Tool (Version 7.1) (Hu et al. 2011). Only human orthologs with a DIOPT score > 2 are shown.