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. 2019 Apr 11;13:1163–1170. doi: 10.2147/DDDT.S190155

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© 2019 Ouyang et al. This work is published and licensed by Dove Medical Press Limited

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Histological assessment (×200).

Notes: Rats were given an intragastric injection of Umb (20 and 40 mg/kg) once a day from day 21 to 28 after the administration of FCA. HE staining was done to study cellular infiltration (►), synovial tissue vasodilation and congestion (<img>), and articular cartilage lesion (→). Representative histological changes in joint tissues were obtained from mice of different groups. Values represent the mean ± SD and are representative of two independent experiments. ^##P<0.01 indicates significant difference from the values in the control group; **P<0.01 indicates significant difference from the values in the AA group.

Abbreviations: Umb, umbelliferone; FCA, Freund’s complete adjuvant; AA, adjuvant arthritis; DS, diclofenac sodium.