Table S1.
All measurement results
| Soluble protein markers | Day 1 | Day 2 | P-value |
|---|---|---|---|
| IL1βa | 46.5 (27.5, 65.5) | 63.0 (39.7, 86.3) | 0.036 |
| IL5a | 6.4 (3.5, 9.2) | 11.8 (4.6, 18.9) | 0.129 |
| IL6a | 352.0 (208.2, 495.8) | 337.4 (186.3, 488.5) | 0.396 |
| IL8a | 1,551.1 (1,076.5, 2,025.7) | 1,648.1 (1,344.2, 1,951.9) | 0.072 |
| IL10b | 0.4 (0.0, 1.8) | 0.9 (0.3, 1.7) | 0.213 |
| IL13b | 0.5 (0.2, 1.0) | 0.8 (0.3, 1.4) | 0.152 |
| IL33b | 1.6 (0.0, 10.1) | 4.1 (0.0, 13.1) | 0.511 |
| sRAGEb | 406.3 (39.3, 1,244.3) | 274.6 (77.5, 1,238.4) | 0.588 |
| TNFαa | 85.8 (18.8, 152.7) | 109.4 (59.6, 159.2) | 0.039 |
| VEGFa | 2,584.4 (2,159.1, 3,009.7) | 2,869.7 (2,402.8, 3,336.6) | 0.112 |
| IgG autoantibodies | |||
| Aggrecanb | 568.3 (501.5, 707.6) | 556.8 (462.9, 698.9) | 0.665 |
| Amyloida | 89.2 (66.9, 111.5) | 114.2 (67.9, 160.5) | 0.318 |
| CENP-Bb | 3,071.7 (2,490.1, 4,090.3) | 3,042.8 (2,820.1, 4,063.2) | 0.951 |
| Collagen Ib | 278.1 (223.6, 390.4) | 278.7 (207.4, 333.7) | 0.977 |
| Collagen IIb | 301.2 (232.0, 638.0) | 311.3 (198.8, 765.1) | 0.859 |
| Collagen IVb | 116.9 (46.8, 344.4) | 130.5 (56.1, 464.1) | 0.269 |
| Cytochrome Cb | 795.4 (637.4, 989.6) | 883.4 (623.6, 1,016.4) | 0.982 |
| Cytokeratin 18b | 933.3 (433.9, 1,920.7) | 838.1 (302.5, 1,916.6) | 0.517 |
| Elastina | 761.9 (643.2, 880.7) | 684.3 (617.9, 750.7) | 0.106 |
| HSP47a | 407.5 (253.1, 562.0) | 359.0 (241.7, 476.3) | 0.914 |
| HSP70b | 5,369.5 (4,440.2, 6,252.3) | 5,515.1 (4,684.1, 6,567.3) | 0.214 |
| SS-B ba | 4,033.8 (3,545.6, 4,790.4) | 4,201.5 (3,866.6, 5,156.0) | 0.387 |
| Vimentina | 365.1 (282.1, 448.1) | 432.6 (306.8, 558.3) | 0.178 |
| IgM autoantibodies | |||
| Aggrecanb | 84.0 (0.0, 465.1) | 111.3 (0.0, 709.4) | 0.117 |
| Amyloidb | 23.6 (1.0, 101.1) | 18.9 (1.5, 85.9) | 0.600 |
| CENP-Bb | 3,885.5 (2,596.2, 8,974.4) | 6,131.3 (2,557.9, 11,631.8) | 0.014 |
| Collagen Ia | 284.1 (183.4, 384.8) | 257.0 (151.6, 362.5) | 0.301 |
| Collagen IIb | 463.6 (12.4, 1,147.2) | 338.3 (8.6, 1,614.4) | 0.954 |
| Collagen IVb | 9.2 (0.3, 278.7) | 1.4 (0.0, 433.2) | 0.520 |
| Cytochrome Cb | 8,572.7 (7,913.6, 11,828.1) | 9,157.1 (6,940.2, 10,326.5) | 0.631 |
| Cytokeratin 18a | 6,480.5 (3,560.2, 9,400.8) | 5,846.3 (3,456.4, 8,236.1) | 0.939 |
| Elastina | 10,074.5 (9,025.2, 11,123.7) | 10,311.0 (8,986.3, 11,635.7) | 0.754 |
| HSP47b | 374.2 (132.6, 801.7) | 508.9 (177.9, 1,043.8) | 0.078 |
| HSP70b | 6,132.8 (4,592.6, 7,867.5) | 6,077.0 (4,628.5, 9,365.8) | 0.238 |
| SS-Bb | 5,240.3 (4,630.9, 7,250.0) | 5,471.9 (4,618.4, 6,972.6) | 0.532 |
| Vimentina | 815.8 (510.0, 1,121.5) | 753.3 (477.8, 1,028.9) | 0.829 |
| Sputum cell counts | |||
| Neutrophils (%)b | 75.0 (53.3, 88.6) | 70.5 (53.2, 85.9) | 0.235 |
| Macrophages (%)b | 19.0 (6.7, 42.5) | 23.3 (9.1, 44.2) | 0.400 |
| Eosinophils (%)b | 2.5 (1.3, 4.0) | 2.2 (1.2, 4.5) | 0.722 |
| Lymphocytes (%)b | 1.2 (0.5, 1.7) | 1.0 (0.4, 1.4) | 0.345 |
Notes:
a
Day 1 – day 2 data with normal distribution or logarithmic normal distribution were analyzed by paired t-test.
b
Non-normally distributed day 1 – day 2 data were analyzed by Wilcoxon test.
Abbreviations: CENP-B, centromere protein B; HSP70, heat shock protein 70; IL, interleukin; INF-γ, interferon-γ; sRAGE, the soluble receptor for advanced glycation end-products; SS-B, La/Sjögren syndrome type B antigen; TNFα, tumor necrosis factor-α; VEGF, vascular endothelial growth factor.