Table S2.
Comparison of measurements between groups
| Soluble protein markers | Healthy | Stable COPD | P-value |
|---|---|---|---|
| IL1βb | 22.1 (13.3, 27.7) | 25.8 (4.8, 101.9) | 0.690 |
| IL5b | 1.3 (0.2, 4.7) | 6.1 (0.8, 10.1) | 0.153 |
| IL6b | 102.1 (21.9, 168.6) | 381.8 (57.1, 797.5) | 0.075 |
| IL8b | 1,171.2 (863.2, 1,445.0) | 1,302.6 (906.3, 1,721.0) | 0.463 |
| IL10b | 0.2 (0.0, 0.7) | 0.6 (0.1, 2.2) | 0.094 |
| IL13b | 0.6 (0.3, 1.0) | 0.4 (0.1, 1.0) | 0.850 |
| IL33b | 0.6 (0.0, 5.3) | 2.9 (0.0, 14.4) | 0.351 |
| sRAGEb | 339.6 (195.1, 3,188.6) | 473.0 (16.4, 1,043.1) | 0.201 |
| TNFαb | 28.9 (0.0, 44.4) | 26.7 (0.0, 104.0) | 0.680 |
| VEGFb | 2,549.7 (2,326.0, 3,093.1) | 2,371.8 (1,574.1, 3,308.6) | 0.438 |
| IgG autoantibodies | |||
| Aggrecanb | 531.1 (474.3, 812.0) | 569.6 (503.4, 622.5) | 0.863 |
| Amyloidb | 86.7 (56.0, 95.2) | 81.8 (38.4, 136.0) | 0.825 |
| CENP-Bb | 3,994.0 (2,907.8, 4,956.0) | 2,847.6 (2,430.3, 3,878.2) | 0.099 |
| Collagen Ia | 356.8 (200.4, 513.2) | 288.1 (243.9, 332.4) | 0.357 |
| Collagen IIb | 408.4 (293.6, 1,000.9) | 263.6 (211.7, 536.9) | 0.073 |
| Collagen IVb | 149.9 (41.2, 658.3) | 104.8 (48.1, 172.6) | 0.363 |
| Cytochrome Cb | 665.9 (566.8, 763.6) | 902.0 (697.4, 1,028.0) | 0.008 |
| Cytokeratin 18b | 843.0 (278.0, 2,817.3) | 945.3 (508.9, 1,932.7) | 0.712 |
| Elastinb | 706.2 (661.3, 809.3) | 742.3 (546.5, 869.0) | 0.863 |
| HSP47b | 274.3 (166.0, 585.9) | 206.0 (108.2, 645.3) | 0.712 |
| HSP70b | 5,640.2 (4,735.5, 7,712.8) | 5,016.0 (4,255.8, 5,498.5) | 0.176 |
| SS-Bb | 3,771.4 (3,562.4, 4,298.6) | 4,411.1 (3,419.8, 5,113.1) | 0.228 |
| Vimentinb | 295.8 (284.3, 574.1) | 301.6 (221.5, 474.8) | 0.313 |
| IgM autoantibodies | |||
| Aggrecanb | 0.0 (0.0, 30.8) | 148.5 (1.2, 519.3) | 0.006 |
| Amyloidb | 45.8 (0.0, 106.9) | 13.6 (1.1, 106.9) | 0.843 |
| CENP-Bb | 3,659.3 (2,152.0, 6,249.1) | 4,134.9 (2,908.3, 12,490.8) | 0.325 |
| Collagen Ib | 283.6 (95.6, 365.7) | 199.1 (93.6, 383.1) | 0.941 |
| Collagen IIb | 463.9 (0.0, 1,252.4) | 463.3 (109.0, 1,221.0) | 0.336 |
| Collagen IVb | 1.2 (0.0, 321.8) | 20.8 (1.1, 307.6) | 0.359 |
| Cytochrome Ca | 11,815.6 (9,060.0, 14,571.2) | 8,710.0 (265.4, 791.2) | 0.036 |
| Cytokeratin 18b | 3,926.2 (1,233.7, 6,578.3) | 4,046.7 (845.2, 12,122.9) | 0.863 |
| Elastina | 10,719.3 (8,817.8, 12,620.8) | 9,769.0 (8,409.5, 11,128.6) | 0.396 |
| HSP47b | 232.2 (117.3, 930.8) | 416.4 (127.0, 782.3) | 0.806 |
| HSP70b | 5,364.2 (3,779.5, 7,710.8) | 6,418.4 (4,536.1, 7,907.4) | 0.572 |
| SS-Bb | 5,831.1 (4,664.5, 10,809.2) | 5,000.8 (4,604.1, 6,589.2) | 0.446 |
| Vimentinb | 677.7 (504.5, 1,471.3) | 512.3 (278.7, 835.2) | 0.268 |
| Sputum cell counts | |||
| Neutrophils (%)a | 53.3 (39.3, 67.3) | 77.4 (70.7, 84.2) | 0.001 |
| Macrophages (%)b | 51.2 (30.2, 58.0) | 15.1 (4.6, 23.9) | 0.001 |
| Eosinophils (%)a | 1.6 (0.7, 2.5) | 3.6 (2.5, 4.7) | 0.004 |
| Lymphocytes (%)b | 1.4 (1.1, 2.0) | 0.9 (0.4, 1.7) | 0.249 |
Notes:
a
Data with normal distribution were expressed as mean and 95% CI and analyzed by t-test.
b
Data with non-normal distribution were expressed as median and interquartile range (IQR) and analyzed by Mann–Whitney U test.
Abbreviations: CENP-B, centromere protein B; HSP70, heat shock protein 70; IL, interleukin; INF-γ, interferon-γ; sRAGE, the soluble receptor for advanced glycation end-products; SS-B, La/Sjögren syndrome type B antigen; TNFα, tumor necrosis factor-α; VEGF, vascular endothelial growth factor.