Table 4.

Clinical characteristics per PPA variant

	PPA variant
Clinical characteristics	Whole Group (=33)	PPA-G (n=14)	PPA-S (n=6)	PPA-L (n=13)
Age at onset, mean (SD)	68.55 (7.49)	68.86 (7.74)	66.17 (5.27)	69.31 (7.85)
Symptom onset time, median (IQR)	2 (1)	2 (1)	2.5 (1.75)	3 (1.25)
Apraxia of Speech (AoS), n (%)	7 (21%)	7 (50%)	0 (0%)	0 (0%)
First symptom
Word finding, n (%)	22 (67%)	8 (57%)	2 (33%)	12 (92%)
Comprehension, n (%)	2 (6%)	0 (0%)	1 (17%)	1 (8%)
Naming, n (%)	5 (15%)	2 (14%)	3 (50%)	0 (0%))
Effortful speech/Articulation, n (%)	4 (12%)	4 (29%	0 (0%)	0 (0%)
Structural imaging (brain MR/CT)
Normal, n (%)	11 (33%)	3 (21%)	1 (17%)	7 (53%)
Atrophy, n (%)	17 (51%)	10 (71%)	3 (50%)	4 (31%)
Not available, n (%)	5 (15%)	1 (7%)	2 (33%)	2 (23%)
Functional imaging (brain PET/SPECT)
Normal, n (%)	8 (24%)	2 (15%)	2 (33%)	4 (31%)
Abnormal, n (%)	12 (36%	5 (35%)	0 (0%)	7 (54%)
Not available, n (%)	13 (40%)	7 (50%)	4 (67%)	2 (15%)

Notes. PPA-G = Primary progressive aphasia – Agrammatic/Nonfluent variant, PPA-S = Primary progressive aphasia – semantic variant, PPA-L = Primary progressive aphasia – logopenic variant, SD= standard deviation, MR = magnetic resonance, CT= computerized tomography, PET= Positron emission tomography, SPECT= Single-photon emission computed tomography