Table 3.
Hazard ratios (95% CI) for all-cause mortality
FGF23 Trajectory |
Low Stable |
Low Increasing |
Elevated Increasing |
Elevated Decreasing |
Elevated Stable |
---|---|---|---|---|---|
Deaths N (%) |
67 (38) | 64 (43) | 92 (34) | 43 (39) | 75 (33) |
Models and Analysis | |||||
Unadjusted | 1.04 (0.75-1.45) |
0.97 (0.69-1.36) |
0.93 (0.68-1.26) |
1.21 (0.83-1.77) |
Reference |
Model 1: age, race, sex | 0.73 (0.52-1.04) |
0.77 (0.54-1.09) |
0.78 (0.57-1.07) |
0.96 (0.65-1.41) |
Reference |
Model 2: model 1 + diabetes, cardiovascular disease, years on dialysis, Kt/V and Flux randomization arms, AV access, serum albumin | 0.65 (0.45-0.92) |
0.70 (0.49-1.00) |
0.73 (0.54-1.02) |
0.87 (0.59-1.29) |
Reference |
Model 3: model 2 + calcium, phosphorus, PTH, 25(OH)D, 1,25(OH)2D, and inflammatory markers | 0.62 (0.42-0.92) |
0.71 (0.48-1.03) |
0.75 (0.55-1.05) |
0.83 (0.55-1.24) |
Reference |
Model 4: model 3 + baseline vitamin D analog use | 0.61 (0.41-0.92) |
0.70 (0.48-1.03) |
0.75 (0.54-1.04) |
0.83 (0.55-1.23) |
Reference |
Model 5: model 4 + residual kidney function | 0.61 (0.41-0.91) |
0.70 (0.48-1.03) |
0.75 (0.54-1.04) |
0.82 (0.55-1.23) |
Reference |