Table 3.
Adjusteda early developmental and pregnancy outcomes (adjusted mean, 95% CI) by quartiles of PCA-derived factor scores from SG-adjusted urinary phenols and phthalate metabolite concentrations among 420 women undergoing 648 IVF cycles in the EARTH Study.
| Total Oocyte Yield (n) | MII Oocyte Yield (n) | Endometrial wall thickness (mm) | Fertilization (rate) | Implantation (probability) | Clinical Pregnancy (probability) | Live Birth (probability) | |
|---|---|---|---|---|---|---|---|
| DEHP factor | |||||||
| Q1 | 11.1 (10.2, 12.0) | 9.3 (8.5, 10.1) | 10.1 (9.7, 10.5) | 0.71 (0.67, 0.75) | 0.56 (0.47, 0.64) | 0.48 (0.39, 0.56) | 0.37 (0.29, 0.46) |
| Q2 | 11.7 (10.9, 12.6) | 9.7 (9.0, 10.5) | 10.6 (10.2, 10.9) | 0.72 (0.69, 0.75) | 0.60 (0.51, 0.67) | 0.51 (0.43, 0.59) | 0.44 (0.36, 0.52) |
| Q3 | 10.7 (9.9, 11.6) | 8.9 (8.2, 9.6) | 10.0 (9.6, 10.3) | 0.68 (0.64, 0.71) | 0.55 (0.47, 0.63) | 0.50 (0.42, 0.58) | 0.42 (0.34, 0.50) |
| Q4 | 10.9 (10.0, 11.9) | 9.2 (8.4, 10.1) | 10.2 (9.8, 10.6) | 0.74 (0.70, 0.78) | 0.48 (0.38, 0.57) | 0.42 (0.33, 0.51) | 0.32 (0.24, 0.41) |
| p, trend | 0.57 | 0.61 | 0.76 | 0.62 | 0.23 | 0.44 | 0.50 |
| non-DEHP factor | |||||||
| Q1 | 10.8 (10.0, 11.7) | 9.0 (8.3, 9.8) | 10.2 (9.9, 10.6) | 0.71 (0.67, 0.75) | 0.58 (0.50, 0.66) | 0.53 (0.45, 0.60) | 0.42 (0.34, 0.50) |
| Q2 | 11.1 (10.2, 12.0) | 9.3 (8.5, 10.1) | 10.0 (9.8, 10.5) | 0.69 (0.66, 0.73) | 0.55 (0.47, 0.63) | 0.48 (0.40, 0.56) | 0.40 (0.32, 0.48) |
| Q3 | 11.4 (10.5, 12.3) | 9.5 (8.7, 10.3) | 10.2 (9.9, 10.6) | 0.74 (0.70, 0.77) | 0.47 (0.39, 0.55) | 0.40 (0.32, 0.48) | 0.36 (0.29, 0.44) |
| Q4 | 11.3 (10.4, 12.2) | 9.3 (8.6, 10.2) | 10.2 (9.8, 10.6) | 0.71 (0.67, 0.75) | 0.58 (0.50, 0.66) | 0.50 (0.42, 0.58) | 0.37 (0.29, 0.45) |
| p, trend | 0.39 | 0.52 | 0.94 | 0.62 | 0.68 | 0.36 | 0.30 |
| parabens factor | |||||||
| Q1 | 10.8 (9.9, 11.7) | 9.1 (8.4, 10.0) | 10.2 (9.8, 10.6) | 0.70 (0.66, 0.74) | 0.53 (0.45, 0.61) | 0.45 (0.37, 0.53) | 0.37 (0.30, 0.46) |
| Q2 | 11.0 (10.1, 11.8) | 9.1 (8.4, 9.9) | 10.2 (9.7, 10.5) | 0.71 (0.68, 0.75) | 0.59 (0.51, 0.67) | 0.53 (0.45, 0.60) | 0.45 (0.37, 0.53) |
| Q3 | 11.6 (10.7, 12.6) | 9.7 (9.0, 10.5) | 10.1 (9.7, 10.5) | 0.70 (0.66, 0.73) | 0.49 (0.41, 0.57) | 0.44 (0.36, 0.52) | 0.35 (0.28, 0.43) |
| Q4 | 11.2 (10.3, 12.1) | 9.2 (8.4, 10.0) | 10.4 (10.0, 10.8) | 0.74 (0.71, 0.78) | 0.57 (0.49, 0.65) | 0.49 (0.41, 0.57) | 0.38 (0.30, 0.46) |
| p, trend | 0.38 | 0.72 | 0.59 | 0.18 | 0.93 | 0.93 | 0.62 |
a
Models were adjusted for maternal age (continuous), body mass index (continuous), year of IVF treatment cycle (continuous), primary SART infertility diagnosis at study entry (female, male, unknown), having had a previous IUI (yes, no) and scores of the other two factors (continuous).