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Synthesis of a trans-cycloctene derivative of alendronic acid (TCO-BP, 2) and radiolabeling with technetium-99m to generate [99mTc]-TCO-BP (3)
L = OH
Note: The specific structure of Tc-bisphosphonates at the tracer level has not been determined conclusively as it is a mixture of different products.35 A representative monomeric structure is shown here.
