FIG. 2.
Representative images from a patient with multifocal carcinoma in situ (CIS). (A) Images being acquired through direct contact of the Confocal MiniprobeTM tip with the urothelium of the inked cystectomy specimen. (B) Cellular appearance of a normal area of bladder urothelium near the dome. (C) Corresponding normal bladder urothelium near the dome as seen on hematoxylin and eosin (H&E) stain. (D) Dense, arborized urothelial architecture suggestive of hemorrhagic small vessels later found by standard histology to represent CIS. (E) Corresponding appearance of the area seen on H&E stain showing denuded mucosa commonly seen with CIS. Scale bar represents 50 μm in (B) and (D).