Summary of results J: Relief of photophobia within two hours in placebo‐controlled studies | |||||||||
Route of administration | Dose (mg) | Number of | Number with outcome/total | Percent with outcome | Relative benefit (95% CI) | NNT (95% CI) | |||
Studies | Participants | Active | Placebo | Active | Placebo | ||||
In participants with moderate or severe baseline pain | |||||||||
Oral | 25 | 3 | 411 | 97/240 | 35/171 | 40 | 20 | 1.8 (1.3 to 2.5) | 5.0 (3.5 to 8.9) |
Oral | 50 | 6 | 1144 | 284/638 | 160/506 | 45 | 32 | 1.4 (1.2 to 1.7) | 7.8 (5.4 to 14) |
Oral | 100 | 9 | 2494 | 834/1703 | 201/791 | 49 | 25 | 1.9 (1.6 to 2.1) | 4.2 (3.7 to 5.1) |
Subcutaneous | 6 | 3 | 631 | 245/343 | 105/288 | 71 | 36 | 1.9 (1.6 to 2.2) | 2.9 (2.4 to 3.6) |
Intranasal | 20 | 3 | 1021 | 314/643 | 89/378 | 49 | 24 | 2.1 (1.7 to 2.5) | 4.0 (3.2 to 5.1) |
In participants with mild baseline pain | |||||||||
Oral | 50 | 3 | 483 | 125/237 | 44/246 | 53 | 18 | 3.0 (2.2 to 4.0) | 2.9 (2.3 to 3.7) |
Oral | 100 | 3 | 475 | 131/229 | 44/246 | 57 | 18 | 3.2 (2.4 to 4.3) | 2.5 (2.1 to 3.2) |