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. 2014 May 27;2014(5):CD009108. doi: 10.1002/14651858.CD009108.pub2
Summary of results K: Relief of phonophobia within two hours in placebo‐controlled studies
Route of administration Dose
 (mg) Number of Number with outcome/total Percent with outcome Relative benefit
 (95% CI) NNT (95% CI)
Studies Participants Active Placebo Active Placebo
In participants with moderate or severe baseline pain
Oral 50 4 852 244/490 134/362 50 37 1.4 (1.2 to 1.6) 7.8 (5.1 to 16)
Oral 100 7 2118 736/1492 164/626 49 26 1.8 (1.6 to 2.1) 4.3 (3.7 to 5.3)
Subcutaneous 6 3 572 223/310 101/262 72 39 1.8 (1.5 to 2.2) 3.0 (2.4 to 3.9)
Intranasal 20 3 933 309/594 93/339 52 27 1.9 (1.6 to 2.3) 4.1 (3.3 to 5.4)
In participants with mild baseline pain
Oral 50 3 413 105/202 37/211 52 18 3.0 (2.2 to 4.2) 2.9 (2.3 to 3.9)
Oral 100 3 400 120/189 37/211 63 18 3.7 (2.7 to 5.1) 2.2 (1.8 to 2.7)