Headache relief at one hour in active‐controlled studies
Route of administration	Dose (mg)	Comparator	Number of		Number with outcome/total		Percent with outcome		Relative benefit (95% CI)	NNT (95% CI)
			Studies	Participants	Active	Comparator	Active	Comparator
In participants with moderate or severe baseline pain
Oral	25	Rizatriptan 5 mg	2	2210	375/1117	404/1093	34	37	0.91 (0.81 to 1.0)	Not calculated
Oral	25	Rizatriptan 10 mg	2	2231	375/1117	456/1114	34	41	0.82 (0.74 to 0.91)	‐14 (‐8.8 to ‐30)
Oral	50	Effervescent ASA 1000 mg	2	726	86/359	113/367	24	31	0.78 (0.61 to 0.99)	‐15 (‐7.5 to ‐270)
Oral	50	Zolmitriptan 2.5 mg	2	1609	330/814	318/795	41	40	1.0 (0.90 to 1.1)	Not calculated
Oral	50	Zolmitriptan 5 mg	2	1633	330/814	320/819	41	39	1.0 (0.92 to 1.2)	Not calculated
Oral	50	Rizatriptan 5 mg	2	2209	409/1116	404/1093	37	37	0.99 (0.89 to 1.1)	Not calculated
Oral	50	Rizatriptan 10 mg	2	2230	409/1116	456/1114	37	41	0.90 (0.81 to 1.0)	Not calculated
Oral	50	Eletriptan 40 mg	2	721	90/362	90/359	25	25	0.99 (0.77 to 1.3)	Not calculated
Oral	50	Eletriptan 80 mg	2	706	90/362	119/344	25	35	0.72 (0.57 to 0.91)	‐10 (‐6.1 to ‐33)
Oral	100	Eletriptan 40 mg	3	2263	282/1130	368/1133	25	32	0.77 (0.68 to 0.88)	‐13 (‐8.9 to ‐26)
Oral	100	Eletriptan 80 mg	2	604	68/299	106/305	23	35	0.65 (0.50 to 0.84)	‐8.3 (‐5.2 to ‐21)
Oral	100	Rizatriptan 10 mg	2	936	120/460	163/476	26	34	0.76 (0.62 to 0.93)	‐12 (‐7.1 to ‐43)
Footnotes: ASA ‐ acetyl salicylic acid, aspirin