Table 5.
Clinical validity: one-way analyses of variance comparing mean EQ-5D-3L and SF-6D health utility index scores of caregivers with children who have different demographic characteristics, n = 224
| Child measure | n (%)a | Caregiver quality of life measures [mean (SD)] | |
|---|---|---|---|
| SF-6D index | EQ-5D-3L index | ||
| Child age (years)b | |||
| < 8.4 | 135 (60) | 0.736 (0.12) | 0.848 (0.15) |
| ≥ 8.4 | 89 (40) | 0.749 (0.12) | 0.846 (0.12) |
| Child IQb | |||
| Low IQ (≤ 70) | 105 (53) | 0.739 (0.12) | 0.848 (0.14) |
| High IQ (> 70) | 92 (47) | 0.740 (0.11) | 0.853 (0.12) |
| Child DSM-IV diagnosisb | |||
| Autism | 160 (73) | 0.747 (0.12) | 0.855 (0.13) |
| Asperger’s syndrome | 19 (9) | 0.694 (0.13) | 0.779 (0.16) |
| PDD-NOS | 39 (18) | 0.741 (0.11) | 0.854 (0.14) |
| Child ADOS severityb | |||
| ≥ 7.2 | 88 (43) | 0.742 (0.12) | 0.843 (0.12) |
| < 7.2 | 117 (57) | 0.745 (0.11) | 0.863 (0.14) |
| Child PedsQL™ total scorec | |||
| < 63.0 | 91 (47) | 0.705 (0.11)* | 0.833 (0.13) |
| ≥ 63.0 | 103 (53) | 0.770 (0.11)* | 0.870 (0.13) |
| Child HUI-3 indexc | |||
| < 0.659 | 90 (41) | 0.712 (0.12)* | 0.819 (0.13)* |
| ≥ 0.659 | 128 (59) | 0.762 (0.11)* | 0.867 (0.14)* |
| Child Vineland-II compositec | |||
| < 68.4 | 100 (52) | 0.736 (0.12) | 0.852 (0.12) |
| ≥ 68.4 | 94 (48) | 0.748 (0.11) | 0.865 (0.13) |
| Child CBCL total scorec | |||
| ≥ 63.7 | 93 (50) | 0.710 (0.12)* | 0.837 (0.13) |
| < 63.7 | 94 (50) | 0.771 (0.12)* | 0.871 (0.12) |
| Child CSHQc | |||
| ≤ 49.1 | 113 (56) | 0.777 (0.11)* | 0.887 (0.11)* |
| > 49.1 | 89 (44) | 0.698 (0.11)* | 0.808 (0.15)* |
Higher scores on the ADOS severity and CBCL indicate worse problems; higher scores on the PEDSQL™, HUI-3, Vineland-II, and CSHQ indicate better functioning/health
ADOS Autism Diagnostic Observation Schedule, CBCL Child Behavior Checklist, CSHQ Children’s Sleep Habits Questionnaire, DSM-IV Diagnostic and Statistical Manual of Mental Disorders 4th Edition, EQ-5D-3L three-level EuroQoL-5 Dimension, HUI-3 Health Utilities Index Mark 3, PDD-NOS Pervasive Developmental Disorder Not Otherwise Specified, PedsQL™ Pediatric Quality of Life Inventory™, SF-6D Short Form-6 Dimension, Vineland-II Vineland Adaptive Behavior Scales Second Edition
*p < 0.05 a using Bonferroni correction factor such that groups with two, three, or four levels must exhibit a p-value of 0.0500, 0.0167, and 0.0083, respectively
an values may not total to 224 due to missing responses
bRegistry data
cCaregiver-reported child measure