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. 2018 Sep 13;189(2):426–436. doi: 10.1007/s12011-018-1496-6

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© The Author(s) 2018

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 4 — The effects of gadolinium complexes a compounds 1 and 2; b compounds 3 and 4 on thrombin time (TT) (mean ± SD; n = 4) after 2-min incubation in plasma; final volume 210 μL. All tested compounds apart from the highest concentration of compounds 1 and 2 did not affect TT. Compounds 1 and 2 at 1.5 μmol/mL significantly prolonged TT. Statistically significant changes are marked with red frame (p < 0.05)