Fig. 6.

a Effect of gadolinium complexes (1, 2) with iminodiacetic acid derivatives on erythrocyte morphology. Two percent erythrocyte suspension was treated at 37 °C for 60 min with indicated concentrations (0.1–1.5 μmol/mL) of compounds 1–2. Representative phase-contrast images are shown (magnification of 400 times). Compounds 1 and 2 at the highest concentration tested contributed to the formation of echinocytes (marked with arrows). b Effect of gadolinium complexes (3, 4) with iminodiacetic acid derivatives on erythrocytes morphology. Two percent erythrocyte suspension was treated at 37 °C for 60 min with indicated concentrations (0.1–1.5 μmol/mL) of compounds 3–4. Representative phase-contrast images are shown (magnification of 400 times). Single echinocytes were recognized in the case of compound 3