. 2019 Jan 28;23(5):661–668. doi: 10.1007/s10157-019-01695-9

Table 4.

Multivariate-adjusted Cox proportional hazard models for renal events

	H.R.	95% C.I.	p value
Model 1
Gender (male vs female)	2.00	[1.68, 2.39]	< 0.0001
Age (1-year increase)	0.98	[0.97, 0.99]	< 0.0001
BMI	1.02	[1.00, 1.04]	0.1225
History of heart disease	0.84	[0.66, 1.04]	0.1206
Diabetes mellitus	1.38	[1.15, 1.66]	0.0005
Diastoric BP	0.98	[0.97, 0.99]	0.0001
Systoric BP	1.03	[1.02, 1.03]	< 0.0001
Use of diuretics	1.11	[0.93, 1.33]	0.2377
Use of ACE	0.82	[0.68, 0.97]	0.0234
eGFR (1 ml/min/1.73 m² increse)	0.90	[0.89, 0.91]	< 0.0001
Model 2
eGFR variability (intermediate vs lowest)	1.21	[0.98, 1.49]	0.0762
(Highest vs lowest)	1.66	[1.35, 2.04]	< 0.0001
Gender (male vs female)	2.02	[1.70, 2.41]	< 0.0001
Age (1-year increase)	0.98	[0.97, 0.99]	< 0.0001
BMI	1.02	[1.00, 1.04]	0.0823
History of heart disease	0.81	[0.64, 1.01]	0.0687
Diabetes Mellitus	1.29	[1.07, 1.55]	0.0072
Diastoric BP	0.98	[0.97, 0.99]	0.0002
Systoric BP	1.03	[1.02, 1.03]	< 0.0001
Use of diuretics	1.05	[0.88, 1.26]	0.5778
Use of ACE	0.79	[0.66, 0.94]	0.0095
eGFR (1 ml/min/1.73 m² increse)	0.90	[0.89, 0.91]	< 0.0001
Model 3
eGFR variability (intermediate vs lowest)	1.16	[0.94, 1.43]	0.1761
(Highest vs lowest)	1.19	[0.97, 1.48]	0.1057
Gender (male vs female)	1.91	[1.59, 2.29]	< 0.0001
Age (1-year increase)	0.98	[0.97, 0.98]	< 0.0001
BMI	1.02	[0.99, 1.04]	0.1999
History of heart disease	0.75	[0.60, 0.95]	0.0166
Diabetes Mellitus	1.21	[0.99, 1.46]	0.0580
Diastoric BP	0.98	[0.97, 0.99]	< 0.0001
Systoric BP	1.02	[1.02, 1.03]	< 0.0001
Use of diuretics	1.21	[1.01, 1.45]	0.0338
Use of ACE	0.75	[0.63, 0.90]	0.0020
eGFR (1 ml/min/1.73 m² increse)	0.89	[0.88, 0.89]	< 0.0001
eGFR slope (/year)	0.84	[0.83, 0.86]	< 0.0001

H.R. Hazard ratio, C.I. Confidence nterval, BMI body mass index, BP blood pressure, ACE angiotensin converting enzyme