. Author manuscript; available in PMC: 2020 Feb 1.

Published in final edited form as: Am J Ophthalmol. 2018 Oct 31;198:223–261. doi: 10.1016/j.ajo.2018.10.022

TABLE 6.

Probability of Progression to Advanced Age-Related Macular Degeneration Over 5 or 10 Years Based on the Composite Risk Score in the Derivation Cohort

Risk Score	HR	95% CI	P value
5 Years
Quintile 1	Ref
Quintile 2	1.30	0.86 - 1.95	0.213
Quintile 3	2.71	1.89 - 3.90	<0.0001
Quintile 4	3.67	2.59 - 5.20	<0.0001
Quintile 5	5.82	4.16 - 8.16	<0.0001
10 Years
Quintile 1	Ref
Quintile 2	1.72	1.30 - 2.27	0.0001
Quintile 3	3.04	2.35 - 3.93	<0.0001
Quintile 4	4.11	3.19 - 5.29	<0.0001
Quintile 5	5.91	4.61 - 7.58	<0.0001

HR = hazard ratio; CI = confidence interval.

Model for the risk score includes age, sex, race, education, BMI, smoking, baseline macular status, and 13 common and rare genetic variants.