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. 2019 Apr 17;14(4):e0213850. doi: 10.1371/journal.pone.0213850

Fig 5. Sequence alignment of the gyrA (DNA gyrase) gene sequence (5) that confers resistance to quinolones (Nalidixic acid).

Fig 5

Quinolone resistance determining regions (QRDR) were amplified by PCR and sequenced using the primers [56, 57]. The substitution was seen at position 83 (confers high-level resistance) and 87 (confers low-level resistance) as described by [55, 63]. This amino substitution does not alter the stereochemical structure greatly and is therefore unlikely to confer resistance to quinolones on its own. The gyrA reference sequence (X06373.1) was obtained from the NCBI database and accession number KY753823 was generated from the study.