Fig 1. SNP heterogeneity tests at nominal p = .01.
SNPs are either null (a); homogeneous (Hom, c); or truly heterogeneous (Het, d); we also test Hom SNPs in simulations with no subtypes (b). FPR is shown on the log scale. Hom SNPs explain 4% of variance and Het SNPs explain .4% (triangles) or vice versa (circles).