Table 1. Number of genome-wide significant loci for GWAS and GxE GWAS.
Shared describes the number of loci that are significant in both the GWAS and GxE GWAS for the same trait (r2 < .2), while GWAS and GxE GWAS describe the loci unique to that association scan. No loci were found for CHD, insulin, or WHR. Both approaches found a single preT2D locus. We excluded NMR PC 5 because of GxE GWAS inflation.
| Gluc | BMI | LDL | HDL | TG | PC 1 | PC 2 | PC 3 | PC 4 | PC 6 | |
|---|---|---|---|---|---|---|---|---|---|---|
| GWAS | 1 | 0 | 3 | 2 | 6 | 5 | 2 | 0 | 3 | 4 |
| GxE GWAS | 2 | 1 | 2 | 1 | 2 | 1 | 3 | 1 | 1 | 1 |
| Shared | 2 | 0 | 5 | 5 | 3 | 1 | 2 | 0 | 3 | 19 |