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. Author manuscript; available in PMC: 2019 Nov 1.
Published in final edited form as: Biomaterials. 2018 Aug 22;183:200–217. doi: 10.1016/j.biomaterials.2018.08.046

Figure 1. Development and cell fate of oligodendrocyte precursor cells.

Figure 1.

Oligodendrocyte precursor cells maintain various paths of cell fate depending on tissue conditions. (a) Histological stain of NG2+ glia (green) and cell nuclei (blue) in horizontal sections of the adult mouse cortex. Scale bar = 100 μm. Olig2+ oligodendrocytes (green) can be perineuronal (white arrow), residing in close proximity to NeuN+ neuron cell bodies (red) in both the (b) cortex and (c) dentate gyrus of coronal sections of the adult mouse brain. Scale bar = 25 μm. (d) Confocal image of cortical CC1+ myelinating oligodendrocytes (green) and cell nuclei (blue) in horizontal sections of the adult mouse. Scale bar = 100 μm. Oligodendrocyte precursors have been observed in certain regions of the brain to transdifferentiate into neurons and, under specific injury conditions, into reactive astrocytes.