Table 4.

Differences in hemodynamic responses between very preterm adults and controls during easy and hard letter trials

Condition	Region	Peak MNI coordinate [x,y,z] (mm)	Cluster size (voxels)	p value*	Contrast of parameter estimate (mean ± SD) (very preterm; control)
Easy > Rest
Very preterm > control	Right STG, insula, thalamus	[68, –2, 4]	3838	<0.001	–2.65 ± 11.71; –12.39 ± 11.21
Hard > Rest
Very preterm > control	Right STG, insula	[62, –18, –6]	8492	<0.001	0.02 ± 10.12; –11.56 ± 10.27
	Left STG, insula	[–54, –4, 2]	2079	0.02	–3.52 ± 13.56; –15.34 ± 10.86
	Right sensorimotor cortex	[48, –40, 68]	2013	0.02	–1.54 ± 14.16; –12.71 ± 13.99
Hard > Easy
Very preterm < control	Left LOC	[–30, –76, 45]	2356	0.00567	–3.01 ± 19.21; 9.84 ± 16.43
	Right LOC	[43, –82, 30]	1944	0.0185	–2.33 ± 26.59; 6.34 ± 12.06

^*Cluster p values were obtained with z = 2.3, p < 0.05 (corrected for family wise error rate across voxels).

STG = superior temporal gyrus; LOC = lateral occipital cortex.