Table 2. Univariate Predictors for RFS and OS in Patients With HCC.
| Variables | n | RFS |
OS |
||||
|---|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | ||
| Age | 0.816 | 0.371 | |||||
| ≥ 65 | 57 | 1.079 | 0.786 - 0.57 | 1.534 | 0.594 - 3.96 | ||
| < 65 | 76 | 1 | 1 | ||||
| Sex | 0.562 | 0.517 | |||||
| Male | 81 | 1.244 | 0.587 - 2.637 | 1.428 | 0.47 - 4.34 | ||
| Female | 31 | 1 | 1 | ||||
| HBV | 0.258 | 0.905 | |||||
| Yes | 20 | 1.573 | 0.74 - 3.346 | 0.928 | 0.2686 - 3.207 | ||
| No | 92 | 1 | 1 | ||||
| HCV | 0.065 | 0.273 | |||||
| Yes | 61 | 0.543 | 0.283 - 1.043 | 0.594 | 0.233 - 1.512 | ||
| No | 51 | 1 | 1 | ||||
| AFP | 0.004 | 0.009 | |||||
| High | 50 | 2.639 | 1.341 - 5.194 | 3.617 | 1.288 - 10.15 | ||
| Low | 62 | 1 | 1 | ||||
| Cirrhosis | 0.052 | 0.446 | |||||
| Yes | 72 | 0.524 | 0.275 - 0.999 | 0.694 | 0.275 - 1.759 | ||
| No | 40 | 1 | 1 | ||||
| Tumor size | 0.282 | 0.200 | |||||
| ≥ 5 cm | 29 | 1.471 | 0.741 - 2.919 | 1.893 | 0.733 - 4.339 | ||
| < 5 cm | 83 | 1 | 1 | ||||
| TN | 0.939 | 0.884 | |||||
| Multiple | 39 | 1.027 | 0.974 - 0.523 | 0.93 | 0.349 - 2.48 | ||
| Solitary | 73 | 1 | 1 | ||||
| VI | 0.0001 | 0.0007 | |||||
| Yes | 30 | 3.675 | 1.906 - 7.088 | 5.142 | 1.987 - 13.31 | ||
| No | 82 | 1 | 1 | ||||
| Grade | 0.00008 | 0.0002 | |||||
| I-II | 68 | 1 | 1 | ||||
| III-IV | 44 | 3.694 | 1.897 - 7.196 | 6.538 | 2.145 - 19.93 | ||
| TNM stage | 0.001 | 0.01 | |||||
| I-II | 95 | 1 | 1 | ||||
| III-IV | 17 | 3.547 | 1.765 - 7.129 | 3.574 | 1.378 - 9.265 | ||
| Arginase | 0.185 | 0.142 | |||||
| High | 93 | 1.904 | 0.675 - 5.369 | 3.489 | 0.464 - 26.23 | ||
| Low | 19 | 1 | 1 | ||||
| CK19 | 0.0002 | 0.945 | |||||
| Positive | 19 | 4.093 | 2.059 - 8.136 | 1.03 | 0.277 - 3.308 | ||
| Negative | 93 | 1 | 1 | ||||
| Arg-1/CK19 | 0.00008 | 0.963 | |||||
| High/positive | 17 | 4.71 | 2.31 - 9.162 | 1.342 | 0.298 - 3.56 | ||
| Others | 95 | 1 | 1 | ||||
| Arg-1/CK19/TN | 0.02 | 0.884 | |||||
| High/positive/multiple | 7 | 3.556 | 1.371 - 9.221 | 0.93 | 0.349 - 2.479 | ||
| Others | 105 | 1 | 1 | ||||
| Arg-1/CK19/TNM stage | 0.01 | 0.242 | |||||
| High/positive/III/IV | 7 | 4.815 | 0.687 - 13.74 | 2.706 | 0.62 - 11.805 | ||
| Others | 105 | 1 | 1 | ||||
| Arg-1/CK19/VI | 0.00008 | 0.082 | |||||
| High/positive/present | 5 | 8.061 | 3.449 - 18.841 | 3.5 | 1.033 - 12.36 | ||
| Others | 107 | 1 | 1 | ||||
| Arg-1/TNM stage | 0.02 | 0.028 | |||||
| High | 93 | 2.881 | 0.99 - 8.382 | 6.091 | 0.778 - 47.7 | ||
| Low | 19 | 1 | 1 | ||||
| Arg-1/stage III-IV | 0.03 | 0.272 | |||||
| High | 10 | 4.394 | 0.925 - 20.87 | 2.93 | 0.343 - 25.167 | ||
| Low | 7 | 1 | 1 | ||||
| CK19/stage III-IV | 0.338 | 0.972 | |||||
| Positive | 3 | 1.847 | 0.55 - 6.191 | 0.962 | 0.111 - 8.322 | ||
| Negative | 14 | 1 | 1 | ||||
| Arg-1/VI | 0.04 | 0.072 | |||||
| High | 21 | 3.072 | 0.881 - 10.705 | 4.659 | 0.595 - 36.4 | ||
| Low | 9 | 1 | 1 | ||||
| CK19/VI | 0.007 | 0.744 | |||||
| Positive | 7 | 4.295 | 1.591 - 11.594 | 1.253 | 0.330 - 4.747 | ||
| Negative | 12 | 1 | 1 | ||||
HCC: hepatocellular carcinoma; OS: overall survival; RFS: recurrence-free survival; HR: hazard ratio; CI: confidence interval; HBV: hepatitis B virus; HCV: hepatitis C virus; VI: vascular invasion; TN: tumor number; TNM: tumor-node-metastasis; AFP: alpha-fetoprotein; Arg-1: arginase-1; CK19: cytokeratin 19.