Table 3. Multivariate Predictors for RFS and OS in Patients With HCC.
| Variables | RFS |
OS |
||||||
|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | |||
| AFP | 1.629 | 0.613 | 0.7506 | 0.21 | 2.256 | 0.677 | 7.512 | 0.05856 |
| Tumor grade | 2.744 | 1.2402 | 6.072 | 0.01 | 5.9432 | 1.7066 | 20.696 | 0.00512 |
| Vascular invasion | 1.456 | 0.581 | 3.646 | 0.422 | 1.5537 | 0.4325 | 5.582 | 0.49947 |
| TNM stage III/IV | 1.848 | 0.8172 | 4.178 | 0.14 | 1.495 | 0.4721 | 4.734 | 0.49414 |
| CK19 | 3.626 | 1.728 | 7.608 | 0.003 | 0.4419 | 0.122 | 1.601 | 0.21372 |
| Arginase-1/CK19 | 3.125 | 1.5149 | 6.447 | 0.002* | 0.4511 | 0.1241 | 1.639 | 0.22655* |
HCC: hepatocellular carcinoma; OS: overall survival; RFS, recurrence-free survival; HR: hazard ratio; CI: confidence interval; TNM: tumor-node-metastasis; AFP: alpha-fetoprotein; CK19: cytokeratin 19. *This P value was obtained from replacement of single variable CK19 to the combined variable in the Cox regression analysis.