Figure 4.
A chronic HF diet exacerbates hyperglycemia in male, but not female, Pomctm1/tm1 mice and reduces plasma adiponectin while inducing insulin resistance in female Pomcwt/wt mice, but not in male or female Pomctm1/tm1 mice. (A–D) Fasting (A and B) blood glucose and (C and D) plasma adiponectin measured at 21 to 23 wk postweaning for (A and C) male and (B and D) female mice fed either an LF or HF diet from weaning. Data are shown as mean ± SEM (n = 5 to 8). Significant differences were determined using a two-way ANOVA and Tukey post hoc test. *P < 0.05; **P < 0.01. (E, F, I, and J) GTTs and (G, H, K, and L) ITTs were performed on (E, F, G, and H) male and (I, J, K, and L) female mice aged 17 to 18 wk. GTTs and ITTs were performed on the same mice with 1 wk between tests. Data are shown as mean ± SEM (n = 3 to 4). Significant differences for area under the curve were determined using a one-way ANOVA and Tukey post hoc test. *P < 0.05.