. 2019 Mar 11;160(5):1081–1096. doi: 10.1210/en.2018-00924

Table 1.

Energy Consumed, Body Weight, and Feed Efficiency for Male Pomc^wt/wt and Pomc^tm1/tm1 Mice

	Pomc ^wt/wt LF	Pomc ^wt/wt HF	Pomc ^tm1/tm1 LF	Pomc ^tm1/tm1 HF
Fourteen to 28 d postweaning
Energy consumed, kcal	61.78 ± 0.26	75.48 ± 2.41^a	69.01 ± 0.36	82.39 ± 1.78^b
Body weight gained, g	3.59 ± 0.05	4.16 ± 0.11	4.47 ± 0.45	5.15 ± 0.28
% Feed efficiency (g body weight gained/kcal consumed × 100)	5.81 ± 0.06	5.52 ± 0.07	6.47 ± 0.63	6.23 ± 0.21
Energy intake on day 28 (kcal/mouse/d)	10.41 ± 0.08	12.52 ± 0.50^a	11.65 ± 0.30	13.62 ± 0.33^b
Body weight at 28 d, g	22.42 ± 0.31	25.58 ± 0.65^a	24.88 ± 0.16^c	27.66 ± 0.22^b
Twelve to 14 wk postweaning
Energy consumed, kcal	165.77 ± 4.46	193.57 ± 4.54^a	174.20 ± 0.66	210.85 ± 2.48^b
Body weight gained, g	1.32 ± 0.15	1.95 ± 0.38	1.49 ± 0.18	2.50 ± 0.27
% Feed efficiency (g body weight gained/kcal consumed × 100)	0.79 ± 0.08	1.01 ± 0.19	0.85 ± 0.10	1.19 ± 0.13
Energy intake at week 14 (kcal/mouse/wk)	82.07 ± 2.48	96.56 ± 3.26^a	86.97 ± 1.21	104.26 ± 1.46^b
Body weight at 14 wk, g	29.82 ± 0.19	36.63 ± 1.15^a	33.17 ± 0.30	43.62 ± 0.42^b^,^d

Energy consumed, body weight gained, and percentage feed efficiency were calculated for mice fed either an LF or HF diet from weaning. Data were calculated for a period of rapid growth (14 to 28 d postweaning) and at maturity (12 to 14 wk postweaning) and are shown as mean ± SEM for three cages, each housing four mice. Significant differences were determined using a two-way ANOVA and Tukey multiple comparison test.

^{^a}

Pomc ^wt/wt LF vs Pomc^wt/wt HF (P < 0.01, energy consumed 14 to 28 d, body weight at 28 d, energy consumed 12 to 14 wk, body weight at 14 wk; P < 0.05, energy intake at day 28, energy intake at 14 wk).

^{^b}

Pomc ^tm1/tm1 LF vs Pomc^tm1/tm1 HF (P < 0.01, energy consumed 14 to 28 d, energy consumed 12 to 14 wk, energy intake at 14 wk; P < 0.05, body weight at 28 d and energy intake at day 28; P < 0.0001, body weight at 14 wk).

^{^c}

Pomc ^wt/wt LF vs Pomc^tm1/tm1 LF (P < 0.05, body weight at 28 d).

^{^d}

Pomc ^wt/wt HF vs Pomc^tm1/tm1 HF (P < 0.01, body weight at 14 wk).