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. Author manuscript; available in PMC: 2020 Apr 17.
Published in final edited form as: ACS Chem Neurosci. 2019 Feb 20;10(4):2070–2079. doi: 10.1021/acschemneuro.9b00033

Figure 1.

Figure 1.

Collagen-coated, structure-switching E-AB sensors specific to ATP exhibited a quantitative increase in faradaic current in the presence of ATP directly in cell culture media (84% DMEM-high glucose, 15% FBS, and 1% 10,000 U/mL Pen/Strep). (Left) Squarewave voltammograms exhibit an increase in peak current of ~30% after the addition of 1 mM ATP. (Right) The collagen-coated sensor exhibited an observed binding affinity (KD) = 17 ± 3 μM to ATP when the calibration curve was fit to a Langmuir-like isotherm. Data showed and error bars represent the mean and standard deviation of three independently fabricated E-AB sensors using the same experimental conditions.