Table 1.

Serum chemistry panel from control and NNMTi-treated (10 mg/kg) aged mice. p-value calculated using 2-tailed Student’s t-test with Welch’s correction (populations not assumed to have same standard deviations).

Serum marker	Control	Treated	p-value*
Creatine kinase (U/L)	648 ± 229	419 ±88	0.39
AST(U/L)	280 ± 84	248 ± 81	0.79
ALT(U/L)	142 ± 61	110 ± 44	0.69
ALP (U/L)	85 ± 15	75 ± 8	0.55
GGT (U/L)	< 3	< 3
GLDH (U/L)	73 ± 46	103 ± 43	0.66
Amylase(U/L)^	1365 ± 748	1344 ± 554	0.77
Total bilirubin (mg/dL)	0.18 ± 0.03	0.18 ± 0.03	>0.99
BUN (mg/dL)	23 ± 2	43 ± 12	0.17
Glucose (mg/dL)	194 ± 23	173 ± 10	0.43
Cholesterol (mg/dL)	81 ± 3	94 ± 12	0.36
Total protein (g/dL)	4.4 ± 0.2	4.4 ± 0.1	0.91
Albumin (g/dL)	2.4 ± 0.063	2.4 ± 0.048	0.25
Globulin (g/dL)	1.9 ± 0.2	2.2 ± 0.075	0.29
Calcium (mg/dL)	8.7 ± 0.3	8.7 ± 0.2	0.94
Phosphorous (mg/dL)	6.7 ± 0.8	5.6 ± 0.5	0.29
Sodium (mEq/L)	147.5 ± 1.7	153.8 ± 2.8	0.10
Potassium (mEq/L)	5.6 ± 0.5	5.0 ± 0.2	0.30
Chloride (mEq/L)	114.5 ± 1.1	119.5 ± 2.4	0.10

Data represent mean ± SEM; n=4/group

^*, p > 0.05; no significant difference

^{^}, elevated levels in both cohorts suggesting age-related dysfunctions