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. Author manuscript; available in PMC: 2019 Dec 21.
Published in final edited form as: ACS Chem Biol. 2018 Dec 3;13(12):3385–3395. doi: 10.1021/acschembio.8b00910

Figure 1.

Figure 1.

Combined malyngamide C acetate (mgc) and malyngamide I (mgi) biosynthesis pathways from Okeania hirsuta PAB and PAP. Abbreviations: acyl carrier protein (ACP), AcpP (fatty acid synthase acyl carrier protein), acetyltransferase (AcT), adenylation (A), acyltransferase (AT), condensation (C), C-methyltransferase (MT), dehydratase (DH), enoyl-CoA hydratase (ECH), enoyl reductase (ER), halogenase (Hal), hydroxymethylglutaryl-CoA synthase (HCS), ketosynthase (KS), ketoreductase (KR), lipocalin-like (Lip), N-methyltransferase (NMT), O-methyltransferase (OMT), octanoyltransferase (OT), cytochrome P450 (P450), peptidyl carrier protein (PCP), thioester reductase (R). Blue color indicates genes or domains found only in PAB. Orange indicates domains that are structurally present in both PAB and PAP, but active in PAP only. Green genes are present in PAP only. Black colored genes are present in both pathways. 0 – inactive domain. † – structurally present in PAP, catalytic residue absent in PAB, no activity predicted due to KR0.