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. Author manuscript; available in PMC: 2020 May 1.
Published in final edited form as: Biochem Pharmacol. 2019 Jan 30;163:21–31. doi: 10.1016/j.bcp.2019.01.022

Figure 4. Evidence for coupling of A3ARs to KATP channel activation in adult mouse cardiomyocytes.

Figure 4.

Representative whole-cell currents recorded from an isolated cardiomyocyte from either a wild-type (WT) C57B/6 (A), Adora1−/− (B), or Adora3−/− (C) mouse after application of CP-532,903 (1 μM) with corresponding current-voltage relationships of the CP-532,903-elicited current obtained by digital subtraction. D. Summary (n=5–7; means ± SEM) of the effects of CP-532,903 on IKATP showing dependence on expression of the A3 but not the A1AR. Current density was determined at the 0 and +40 mV test pulses from a −40 mV holding potential. All recordings were obtained as described in METHODS in the presence of ZM241385 (100 nM) and PSB603 (100 nM) to block A2A and A2BARs. *P<0.05 vs WT.